President Xi Jinping and Premier Li Keqiang have urged all-out efforts to save the injured and minimize casualties in the Tianjin blasts.
The explosions, which occurred at a warehouse in the north China port city on the night of Aug 12, has killed 50 people and injured more than 700 by 6 pm on Aug 13.
In an instruction, President Xi ordered authorities in Tianjin to spare no effort to treat the injured, search for the missing, and contain the fire as soon as possible.
He also required efforts to find out the cause of the fire and punish those who are accountable for the accident.
Families of the victims and the wounded should be well comforted, President Xi said, adding that the rescue should be conducted in a scientific way to ensure the safety of the rescuers.
He requested authorities in other regions to learn from this accident and check their own potential safety risks and strengthen the management of dangerous goods, to ensure safety of life and property.
Premier Li urged all-out effort to extinguish the fire and asked authorities to intensify search and rescue.
He requested capable medical staff to be convened to treat the injured so as to minimize death from injuries.
The Premier also vowed a thorough investigation of the accident and asked efforts to ensure open and transparent information disclosure to the public.
Meanwhile, he asked governments at all levels to be more responsible in implementing measures that ensure work safety.
A State Council work group led by Minister of Public Security Guo Shengkun has arrived the site to direct rescue and emergency response.